What are the reasons for anemic patients with renal failure?

　　 Cause of anemia in kidney failure also known as renal anemia, renal failure patients have anemia what reason? Kidney experts explained that renal anemia is caused by a variety of reasons to grow into kidney hormone erythropoietin (EPO) produce high plasma creatinine foot or uremia some toxic substances interfere with the metabolism of red blood cells is generated which results in anemia. This interpretation is more abstract, the following, we say something about the specific situation, kidney failure patients have anemia what reason?
　　97% of patients with chronic renal impairment accompanied by anemia, generally, the degree of anemia often consistent with the degree of renal injury. To recognize renal failure anemia, anemia was the first to learn how to lead, and the country's best kidney hospital for you to explain as follows:
　　The reason a renal anemia, bleeding
　　Platelet dysfunction caused by impaired renal function of patients with chronic bleeding tendency and bleeding, especially gastrointestinal bleeding and skin, although not a direct cause of renal anemia caused but can aggravate and accelerate the generation of anemia.
　　Two reasons renal anemia, EPO generate fewer
　　Because renal parenchyma imbalance, involving the generation EPO cells, along with disease progression, EPO produced gradually becomes less, thereby enabling the generation of bone marrow erythroid cells slows down. But it was the blood of patients with renal failure showed EPO levels were normal or above normal, suggesting that perhaps the relative lack of presence of EPO. . In recent years, recombinant human erythropoietin (rhEPO) treatment of renal anemia been satisfactory.
　　Three reasons renal anemia, bone marrow suppression
　　Chronic renal failure or uremia patients with high plasma creatinine there suppression of erythropoiesis substance inhibits in vitro cell culture erythroid progenitor cells mature, later proved to inhibit erythroid colony-forming units (CFU-E) proliferation and hemoglobin synthesis, spermine, spermidine, guanidine, PTH and other imbalances in the body and perhaps after hematopoietic microenvironment and to inhibit bone marrow function.
　　Four reasons renal anemia, red blood cell shortened life expectancy
　　The survey shows that shorten the life span of red blood cells of patients with renal failure is mainly due to the reasons causing the cells, red blood cells the patient entered into the patient's normal that its normal life of red blood cells, whereas the supply of red blood cells in patients with normal creatinine high input to uremia by the patient, whose life is shortened red blood cells after dialysis, life returned to normal red blood cells also show this.
　　But this phenomenon is present in the plasma of patients with renal failure of certain substances interfere with the red blood cell membrane Na pump function, red blood cell fragility. In addition, RBC pentose phosphate shunt metabolism, so generate fewer NADPH, reduced glutathione decreases, no way to eliminate the body of peroxide, thereby enabling an increase in oxygen free radicals, resulting in the red cell membrane lipid peroxidation . Guanidine substances may be one cause of hemolysis, aluminum and silicon inhibit superoxide dismutase (SOD), PTH may also increase the osmotic fragility of cells, resulting in cell membrane stability and integrity of the change five, iron and folic acid lack of chronic renal failure patients often can produce a lack of iron. ① platelet dysfunction resulting in chronic gastric bleeding, resulting in the loss of iron; ② hemodialysis because when plasma remaining in the dialysis membrane and dialysis Louxue; ③ frequent blood tests. Folic acid deficiency is also common in hemodialysis patients. Lack of iron and folic acid affect hemoglobin synthesis.

　　Above my kidney specialist hospital four reasons explained in detail, kidney failure patients if they can control the above circumstances, to find the cause of his body, go to a regular hospital, finding the right treatment plan to stay away from delaying the disease, early recovery up, no longer allow itself plagued by kidney failure.