Cause of
anemia in kidney failure also known as renal anemia, renal failure patients have
anemia what reason? Kidney experts explained that renal anemia is caused by a
variety of reasons to grow into kidney hormone erythropoietin (EPO) produce high
plasma creatinine foot or uremia some toxic substances interfere with the
metabolism of red blood cells is generated which results in anemia. This
interpretation is more abstract, the following, we say something about the
specific situation, kidney failure patients have anemia what reason?
97% of patients with chronic renal impairment accompanied by anemia,
generally, the degree of anemia often consistent with the degree of renal
injury. To recognize renal failure anemia, anemia was the first to learn how to
lead, and the country's best kidney hospital for you to explain as follows:
The reason a renal anemia, bleeding
Platelet dysfunction caused by impaired renal function of patients with
chronic bleeding tendency and bleeding, especially gastrointestinal bleeding and
skin, although not a direct cause of renal anemia caused but can aggravate and
accelerate the generation of anemia.
Two reasons renal anemia, EPO generate fewer
Because renal parenchyma imbalance, involving the generation EPO cells,
along with disease progression, EPO produced gradually becomes less, thereby
enabling the generation of bone marrow erythroid cells slows down. But it was
the blood of patients with renal failure showed EPO levels were normal or above
normal, suggesting that perhaps the relative lack of presence of EPO. . In
recent years, recombinant human erythropoietin (rhEPO) treatment of renal anemia
been satisfactory.
Three reasons renal anemia, bone marrow suppression
Chronic renal failure or uremia patients with high plasma creatinine there
suppression of erythropoiesis substance inhibits in vitro cell culture erythroid
progenitor cells mature, later proved to inhibit erythroid colony-forming units
(CFU-E) proliferation and hemoglobin synthesis, spermine, spermidine, guanidine,
PTH and other imbalances in the body and perhaps after hematopoietic
microenvironment and to inhibit bone marrow function.
Four reasons renal anemia, red blood cell shortened life expectancy
The survey shows that shorten the life span of red blood cells of patients
with renal failure is mainly due to the reasons causing the cells, red blood
cells the patient entered into the patient's normal that its normal life of red
blood cells, whereas the supply of red blood cells in patients with normal
creatinine high input to uremia by the patient, whose life is shortened red
blood cells after dialysis, life returned to normal red blood cells also show
this.
But this phenomenon is present in the plasma of patients with renal failure
of certain substances interfere with the red blood cell membrane Na pump
function, red blood cell fragility. In addition, RBC pentose phosphate shunt
metabolism, so generate fewer NADPH, reduced glutathione decreases, no way to
eliminate the body of peroxide, thereby enabling an increase in oxygen free
radicals, resulting in the red cell membrane lipid peroxidation . Guanidine
substances may be one cause of hemolysis, aluminum and silicon inhibit
superoxide dismutase (SOD), PTH may also increase the osmotic fragility of
cells, resulting in cell membrane stability and integrity of the change five,
iron and folic acid lack of chronic renal failure patients often can produce a
lack of iron. ① platelet dysfunction resulting in chronic gastric bleeding,
resulting in the loss of iron; ② hemodialysis because when plasma remaining in
the dialysis membrane and dialysis Louxue; ③ frequent blood tests. Folic acid
deficiency is also common in hemodialysis patients. Lack of iron and folic acid
affect hemoglobin synthesis.
Above my kidney specialist hospital four reasons explained in detail,
kidney failure patients if they can control the above circumstances, to find the
cause of his body, go to a regular hospital, finding the right treatment plan to
stay away from delaying the disease, early recovery up, no longer allow itself
plagued by kidney failure.