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Kidney specialists answer :: Hello! According to the information given by your point of view, if no record of diabetes, it indicates that the disease into renal failure azotemia, since renal cell damage, glomerular sclerosis, fibrosis, toxins accumulate in the body without causing discharge method and other indicators of elevated serum creatinine. IgA nephropathy, an autoimmune kidney disease, refers to the body to produce anti-microbial antigen IgA antibody, a lot of IgA and IgA immune complex deposition in the mesangial activation of the alternative complement pathway, causing kidney damage diseases.