What causes IgA nephropathy? IgA nephropathy causes roughly divided into the following four kinds.
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IGA nephropathy during the initial inflammatory response, when the disease, renal glomerular mesangial cells of patients damaged by inflammatory stimuli will generate inflammatory cytokines, thus resulting in a large number of immune complex precipitation in the patient's kidneys, and ultimately lead to disease production.
2, IGA nephropathy has a genetic predisposition
IGA nephropathy incidence of patient population investigated, some patients will have IGA nephropathy familial aggregation phenomenon, which shows that IGA nephropathy have a genetic predisposition to a certain extent.
3, the main immune complexes IGA IGA nephropathy patient participation pathogenic abnormal precipitation
IGA nephropathy patient mesangial area of immune complexes precipitated a lot of substance, which is the primary immune complexes IGA IGA nephropathy patients with glomerular mesangial cells with high affinity binding after two patients can cause kidney inherent cells transformed phenotype, which results in generation of the disease.
4, infection also causes IGA nephropathy
Colds, tonsillitis, fever, showing the naked eye or urine occult blood, bounce back and forth as the reason for the infection, most patients showed occult blood in the body to the hospital for medical treatment when abnormal.
