why do kidney failure patients have metabolic disorder?

why do kidney failure patients have metabolic disorder

In the early stage of chronic kidney failure, concentration dilution function of kidney tubules and glomerular filtration rate (GFR) decrease but do not decline seriously. With the progression of kidney disease, kidney nephrons become less and GFR has a further decline. This will affect water, electrolytes and acid-based balance. A series of metabolic disorders occur.

http://m.kidney-cares.org/kidney-failure-symptoms-complications/why-do-kidney-failure-patients-have-metabolic-disorder.html