Are there many reasons for the onset of chronic renal failure ?
Patients asked : What is the etiology of chronic renal failure in the etiology of chronic renal failure and chronic renal failure more than you etiology etiology of chronic renal failure is extremely broad , almost all develop worsening kidney disease can cause chronic renal failure ? ? . Acute renal failure is no cure , short term nor death can also be a direct transition to chronic renal failure.
The etiology of chronic renal failure :
First, the progression of chronic glomerulonephritis development to final illness is the most common cause of chronic renal failure.
Second , interstitial nephritis is a series of mainly involving the renal interstitial and tubular disease , also known as an interstitial kidney tubules . Their complex etiology , clinical common disease, urinary system diseases accounted for 25% to 33 % living in chronic renal failure in the second.
Third , infections: bacteria, viruses, fungi , and other Plasmodium invasion between renal interstitial and tubular , which represents diseases such as chronic pyelonephritis. Hernia and other malignant diseases .
Fourth , immune injury : common allergy medicines such as penicillin , sulfonamides , autoimmune diseases such as systemic lupus erythematosus, scleroderma , dermatomyositis involving the kidneys.
Fifth, toxic substances Damage: aminoglycoside antibiotics such as contrast agent kidney damage , heavy metal salts such as mercury , lead, arsenic , gold and other damage kidneys.
Sixth, renal blood supply disorders: such as renal arteriosclerosis, renal artery stenosis.
Sixth, metabolic abnormalities : If hyperuricemia, hypercalcemia, hypokalemia long .
Seventh, the physical reasons : prolonged exposure to X-ray , X-ray radiation and other malignancies .
Eighth, urethral blockage : obstruction caused by bladder, ureter urine reflux so pelvis, ureter and renal interstitial pressure increased damage , such as co-infection is increasingly important disease.
Ninth, direct tumor infiltration of renal interstitial : such as leukemia , lymphoma , cancer metastasis resulting in renal interstitial damage.
Tenth , hereditary diseases: such as polycystic kidney disease, kidney cysts.
Eleventh, Balkan nephritis : are unexplained kidney interstitial disease , mainly produced in southern Europe .
XII, arteriosclerosis , high blood pressure and then at this time of the first injury of tubular glomerular injury , renal damage and glomerulonephritis first renal tubular damage is not the same then .
XIII, secondary to metabolic diseases such as diabetes, gout kidney , amyloidosis , etc. .
XIV , machine management
A glomerular filtration theory over more and more unbalanced when residual renal glomerular tissue due to excessive compensatory filtration , ultimately resulting in the loss of glomerular sclerosis have features such as 85% nephrectomy animals , 3 months You can see the remnants of glomerular hypertrophy, vacuolation of epithelial cells , foot process fusion , six months can be seen mesangial area increases; glomerular basement membrane endothelial , epithelial cell shedding , ultimately resulting in focal , segmental glomerulosclerosis , kidney filtration rate is further reduced, further deterioration of renal function .
2 righting a wrong doctrine imbalance in chronic renal failure, increase the body of toxic substances, poisons the body in order to clear some compensation , the results showed a new imbalances , such as glomerular filtration rate ( detoxification capacity ) decreased urinary phosphorus excretion fewer , showing hyperphosphatemia , hypocalcemia, stimulating the secretion of parathyroid increased efficacy in renal tubules, increased urinary excretion of phosphorus , so phosphorus decreased , blood calcium increased, returned to normal levels . Elevated serum calcium is deposited in the system itself, which includes the kidneys , the glomerular filtration rate ( detoxification capacity ) is further reduced, further deterioration of renal function .
When the etiology of chronic renal failure, chronic renal failure , glomerular filtration rate ( detoxification capacity ) is low, fewer natriuresis , this time increased natriuretic hormone secretion , proximal tubular sodium reabsorption fewer , but natriuretic hormone on Na +-K +-ATP enzyme inhibitory effect, it makes a lot of cells to transport the steel barriers , forming a new imbalances .
3 uremic toxins doctrine in high creatinine increase of 200 when the body has a variety of substances , including 20 kinds of toxic substances in small molecules ( molecular weight <500 persons molecule ( molecular weight of 500 to 5000 ) and macromolecules ( molecular weight > 5000 ) three categories is the main cause of small molecules comprehensive clinical manifestations such as urea, guanidine , amine . lysates molecular substances such as polypeptides, cells, and bacteria. molecular substances can cause peripheral neuropathy, uremic high creatinine encephalopathy disease , erythropoietin inhibited, insulin inhibits the activity of lipoprotein lipase activity inhibition of platelet function damage, cellular immune dysfunction, sexual dysfunction and exocrine atrophy in chronic renal failure, hyperphosphatemia and hypocalcemia stimulus parathyroid secretion, resulting in intracellular calcium deposition, nerve conduction velocity , increased calcium brain cells, while renal anemia is caused by parathyroid focus reason , in addition to directly affect cardiac function and myocardial cell metabolism .
