Etiology of chronic renal failure and chronic renal failure etiology extremely broad deterioration in almost all developing kidney disease can cause chronic kidney failure. Acute renal failure no cure, short term nor death can direct transition to chronic renal failure. Now common causes are described below:
First, the deterioration of the disease develop chronic glomerulonephritis to the end is the most common cause of chronic renal failure.
Second, interstitial nephritis (Interstitial Nephritis) is a series of mainly involving the renal interstitial and tubular disease, also known as an interstitial nephropathy tubule (Tubulo-Interstitia Nephropa-thy). Their complex etiology, clinical widespread disease, accounting for 25% to 33% of the urinary system diseases, chronic renal failure living in second place.
Third, the infection: bacteria, viruses, fungi, and other inter-Plasmodium invasion renal interstitial and tubular, which represents diseases such as chronic pyelonephritis. Hernia and other malignant diseases.
Fourth, immune damage: universal drug allergies such as penicillin, sulfonamides, autoimmune diseases such as systemic lupus erythematosus, scleroderma, dermatomyositis involving the kidneys.
Fifth, the Toxic Substances Injuries: aminoglycoside antibiotics such as contrast agents damage the kidneys, salts of heavy metals such as mercury, lead, arsenic, gold and other damage to the kidneys.
Sixth, kidney blood supply disorders: such as renal arteriosclerosis, renal artery stenosis.
Sixth, metabolic abnormalities: such as hyperuricemia, hypercalcemia, hypokalemia and so long.
Seventh, the physical reasons: prolonged exposure to X-ray, X-ray radiation and other malignancies.
Eighth, urethral blockage: obstruction caused by bladder, ureter urine reflux make pelvis, ureter and renal interstitial pressure increased damage, such as infection is even more important illnesses.
Ninth, direct tumor infiltration of renal interstitial: such as leukemia, lymphoma, cancer metastasis cause renal interstitial injury.
Tenth, hereditary diseases: such as polycystic kidney disease, kidney cysts.
Eleventh, Balkan nephritis: are unexplained kidney interstitial disease, mainly produced in southern Europe.
XII, high blood pressure arteriosclerosis this time first and then hurt glomerular renal tubular injury, and glomerulonephritis first hurt glomerular renal tubular damage is not the same then.
XIII, secondary to metabolic diseases such as diabetes, gout, kidney, amyloidosis and the like.
XIV, machine processing
1 glomerular filtration doctrine excessive imbalance when more and more residual renal glomerular tissue due to compensatory excessive filtration, ultimately resulting in the loss of glomerular sclerosis have features, such as 85% nephrectomy animals, 3 months you can see the remnants of glomerular hypertrophy, vacuolation of epithelial cells, foot process fusion, six months can be seen mesangial area increases; glomerular basement membrane endothelial, epithelial cell loss, eventually resulting in focal, segmental glomerulosclerosis, kidney filtration rate is further reduced, further deterioration of renal function.
2 righting a wrong doctrine imbalance in chronic renal failure, increase the body of toxic substances, the body in order to remove some of the poison and compensation, the results showed a new imbalances, such as glomerular filtration rate (detoxification capacity) decreased urine phosphorus excretion fewer, showing hyperphosphatemia, hypocalcemia, stimulating the secretion of parathyroid increased efficacy in renal tubules, increased urinary excretion of phosphorus, so phosphorus decreased, blood calcium increased, returned to normal levels. Elevated serum calcium is deposited in the system itself, which includes the kidneys, the glomerular filtration rate (detoxification ability) to further reduce further deterioration of renal function.
When the etiology of chronic renal failure and chronic renal failure, glomerular filtration rate (detoxification capacity) is low, fewer natriuresis, this time to increase natriuretic hormone secretion, proximal tubular sodium reabsorption fewer, but natriuretic hormone on Na + -K + -ATP enzyme inhibition effect, so make a lot of cells to transport steel barriers, forming a new imbalances.
3 uremic toxins doctrine in high creatinine increase when the body has more than 200 kinds of substances, including over 20 kinds of toxic substances in small molecules (molecular weight <500 persons molecule (molecular weight of 500 to 5000) and macromolecules (molecular weight> 5000) three categories of small molecules is the main cause of comprehensive clinical manifestations such as urea, guanidine, amines. lysates molecular substances such as polypeptides, cells and bacteria. middle molecular substances can cause peripheral neuropathy, uremic high creatinine encephalopathy disease, erythropoietin inhibited, insulin inhibits the activity of lipoprotein lipase activity inhibition of platelet function damage, cellular immune dysfunction, sexual dysfunction and exocrine atrophy. chronic renal failure, hyperphosphatemia hypocalcemia stimulus parathyroid secretion, resulting in cell calcium deposition, nerve conduction velocity, increased calcium brain cells, while renal anemia is caused by parathyroid focus reason, in addition to directly affect cardiac function and myocardial cell metabolism .
14.3 is my hospital experts on the etiology of chronic renal failure explained in detail above, and want to make understand the etiology of chronic renal failure patients become more understanding, in order to better treat chronic renal failure, early rehabilitation.
